Scientists at Hallym University detail research in apoptosis.(Report)

According to a study from South Korea, "CD7, one of the galectin-1 receptors, has crucial roles in galectin-1-mediated apoptosis of activated T-cells and T-lymphoma progression in peripheral tissues. In this study, we showed that CD7 promoter activity was increased by NF-kappa B and that this activity was synergistic when Sol was co-expressed in the immature T-cell line L7."

"Site-directed mutagenesis analysis of the CD7 promoter indicated that NF-kappa B specifically bound to the NF-kappa E2 site in cooperation with Sp1. Overexpression of E12 or Twist2 proteins negatively regulated NF-kappa B-mediated activity of the CD7 proximal promoter. In addition, CD7 expression …